In-Situ, from the Latin, means “In the situation” or “in the context.” Surprisingly, this term has been utilized in both hospital-based and academic simulation programs. In hospital-based simulation, In-Situ simulation activities occur in real hospital rooms, operating theatres and various other patient care contexts. This allows the participants to become familiar with the equipment, the overall space, and with the teams with which they may work. Typically, In-Situ simulation is interprofessional, but does not necessarily require it to be so. In academia, some educators refer to any clinical space that represents “real” features of clinical and medical facilities is referred to as “In-Situ.” However, no matter how “real” a simulation space might be, it is not In-Situ, strictly speaking.